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Diuresis occurs initially and theaccumulated salt and water are lost due toimproved renal perfusion and abolition ofmineralocorticoid mediated Na+ retention.

The hypotensiveaction is more marked after parenteral adminis-tration and roughly parallels the adrenergicblocking potency.

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Harlow, Muliak, and Steiger (1997) present a detailed symposium on thepros and cons of null hypothesis significance testing and present a set of eight recommen-dations for the practice of scientific inference, with a discussion of how their symposiumcontributors weigh in on each recommendation. The pilot studies drive modificationsand improvements to the experimental design in an iterative process that may go throughseveral cycles

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